"We are only here to accomplish one mission, to fight the regime and its agents on the ground, including Hezbollah and others," Abu Mohammed al-Golani said in an exclusive interview aired on Al Jazeera on Wednesday.
"Nusra Front doesn’t have any plans or directives to target the West. We received clear orders not to use Syria as a launching pad to attack the US or Europe in order to not sabotage the true mission against the regime. Maybe al-Qaeda does that but not here in Syria," he said.
But his statements did include a warning against the US over its attacks on the armed group, which has been blacklisted a "terrorist organisation" by the US.
"Our options are open when it comes to targeting the Americans if they will continue their attacks against us in Syria. Everyone has the right to defend themselves," he said in an interview with the Doha-based network.
Golani not only accused Western nations of backing the government of President Assad against the rebels, but of also fabricating the "Khorasan" group - which Washington says is a covert faction in Syria that aspires to attack the US.
"The West is targeting Nusra because they know we are the real threat to the Assad regime. This is why they came out and said they are only targeting this group that they called Khorasan," the leader of al-Qaeda's Syria branch said.
"There is nothing called Khorasan group.The Americans came up with it to deceive the public. They claim that this secret group was set up to target the Americans but this is not right."
He also noted that the Islamic State of Iraq and the Levant group (ISIL), which has been accused of rampant atrocities and controls large parts of the country, was a main threat to the Nusra Front.
"Assad forces are fighting us on one end, Hezbollah on another and ISIL on a third front. It is all about their mutual interests."
Alawites will not be targeted
When questioned whether the Nusra Front planned to establish Islamic state in Syria, Golani said that after the whole war is over, all factions and groups in the country will be consulted before considering
"establishing an Islamic state".
Golani also said that his group will not target the country's Alawite minority despite their support for Bashar al-Assad's government.
"The battle does not end in Qardaha, the Alawite village and the birthplace of the Assad clan," he said.
"Our war is not a matter of revenge against the Alawites despite the fact that in Islam, they are considered to be heretics.